Investigation of the cell (osteocytes, fibroblasts and keratinocytes) adhesion and penetration in pores of the titanium pylon in vivo on the laboratory animals (Wistar rats) has been performed. The titanium pylon has been implanted in bone of a rat's thigh residuum. Electronic scanning and morphological analysis demonstrated the certain integration of the pylon with the surrounding tissues. The latter opens a possibility for development of direct skeletal attachment of limb prostheses.