A novel, facile route to beta-fluoroamines by hydrofluorination using superacid HF-SbF(5)

Sébastien Thibaudeau; Agnès Martin-Mingot; Marie-Paule Jouannetaud; Omar Karam; Fabien Zunino

doi:10.1039/b703629a

A novel, facile route to beta-fluoroamines by hydrofluorination using superacid HF-SbF(5)

Chem Commun (Camb). 2007 Aug 14:(30):3198-200. doi: 10.1039/b703629a. Epub 2007 Jun 7.

Authors

Sébastien Thibaudeau¹, Agnès Martin-Mingot, Marie-Paule Jouannetaud, Omar Karam, Fabien Zunino

Affiliation

¹ Université de Poitiers, CNRS UMR 6514, Laboratoire "Synthèse et Réactivité des Substances Naturelles", F-86022 Poitiers Cedex, France. sebastien.thibaudeau@univ-poitiers.fr

PMID: 17653387
DOI: 10.1039/b703629a

Abstract

A range of unsaturated amines and sulfonamides were converted to beta-fluoro nitrogen analogues after hydrofluorination in superacid HF-SbF(5), based on the formation of highly reactive electrophilic intermediates.

MeSH terms

Allyl Compounds / chemistry
Amines / chemical synthesis*
Antimony / chemistry
Fluorides / chemistry
Hydrocarbons, Fluorinated / chemical synthesis*
Hydrofluoric Acid / chemistry

Substances

Allyl Compounds
Amines
Hydrocarbons, Fluorinated
Antimony
Fluorides
Hydrofluoric Acid