Novel antioxidants in anthracycline cardiotoxicity

Cardiovasc Toxicol. 2007;7(2):160-4. doi: 10.1007/s12012-007-0019-z.

Abstract

It has been suggested nitroxides and their amine precursors prevent incidence of damage caused by superoxide and hydroxyl radicals formed during the oxidative metabolism of doxorubicin (DOX) and daunorubicin (DAU). Both doxorubicin and daunorubicin have been associated with cardiac toxicity in both adults and children. The authors herein suggest that cardioprotective molecules modified by nitroxides and their secondary amine precursors can prevent or diminish the anthracycline-induced cardiomyopathy by accumulating in cardiomiocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amines / metabolism
  • Animals
  • Anthracyclines / antagonists & inhibitors*
  • Anthracyclines / toxicity
  • Antibiotics, Antineoplastic / antagonists & inhibitors*
  • Antibiotics, Antineoplastic / toxicity
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use
  • Cyclic N-Oxides / pharmacology
  • Cyclic N-Oxides / therapeutic use
  • Heart Diseases / chemically induced
  • Heart Diseases / prevention & control
  • Humans
  • Nitrogen Oxides / metabolism
  • Spin Labels

Substances

  • Amines
  • Anthracyclines
  • Antibiotics, Antineoplastic
  • Antioxidants
  • Cyclic N-Oxides
  • Nitrogen Oxides
  • Spin Labels
  • tempol