Acquired macrolide resistance in the human intestinal strain Lactobacillus rhamnosus E41 associated with a transition mutation in 23S rRNA genes

Int J Antimicrob Agents. 2007 Oct;30(4):341-4. doi: 10.1016/j.ijantimicag.2007.06.002. Epub 2007 Jul 20.

Abstract

Restriction fragment length polymorphism and DNA sequencing of polymerase chain reaction (PCR) products showed that a Lactobacillus rhamnosus strain of human origin resistant to macrolides, from which no resistance determinants have been detected by specific PCR and microarray screening, contained a heterozygous A-->G transition mutation at position 2058 (Escherichia coli numbering) of its 23S rRNA genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • Drug Resistance, Bacterial / genetics*
  • Gastrointestinal Tract / microbiology
  • Genes, rRNA / genetics
  • Humans
  • Lacticaseibacillus rhamnosus / drug effects*
  • Lacticaseibacillus rhamnosus / genetics*
  • Macrolides / pharmacology*
  • Molecular Sequence Data
  • Point Mutation*
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • RNA, Ribosomal, 23S / genetics*
  • Sequence Analysis, DNA

Substances

  • DNA, Bacterial
  • DNA, Ribosomal
  • Macrolides
  • RNA, Ribosomal, 23S

Associated data

  • GENBANK/EF030190
  • GENBANK/EF030191