Abstract
The Euphorbia hirta ethanolic extract (EH A001) was found to possess a prominent anti-anaphylactic activity. A preventive effect of EH-A001 given by oral route at dose from 100 to 1000 mg/kg was observed against compound 48/80-induced systemic anaphylaxis. At the same range of dose, EH-A001 inhibited passive cutaneous anaphylaxis (PCA) in rat and active paw anaphylaxis in mice. A suppressive effect of EH-A001 was observed on the release of TNF-alpha and IL-6 from anti-DNP-HSA activated rat peritoneal mast cells.
MeSH terms
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Administration, Oral
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Anaphylaxis / chemically induced
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Anaphylaxis / prevention & control*
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Animals
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Dose-Response Relationship, Drug
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Euphorbia*
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Histamine H1 Antagonists / administration & dosage
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Histamine H1 Antagonists / pharmacology*
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Histamine H1 Antagonists / therapeutic use
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Interleukin-6 / biosynthesis
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Mast Cells / drug effects
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Mast Cells / immunology
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Mice
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Passive Cutaneous Anaphylaxis
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Peritoneum / cytology
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Phytotherapy*
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Plant Components, Aerial
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Rats
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Rats, Wistar
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Tumor Necrosis Factor-alpha / biosynthesis
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p-Methoxy-N-methylphenethylamine
Substances
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Histamine H1 Antagonists
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Interleukin-6
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Plant Extracts
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Tumor Necrosis Factor-alpha
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p-Methoxy-N-methylphenethylamine