Setting the stage for S phase

Mol Cell. 2007 Jul 20;27(2):176-177. doi: 10.1016/j.molcel.2007.07.001.

Abstract

In a recent issue of Molecular Cell, Tyagi et al. (2007) show that E2F1, a positive regulator of S phase entry, recruits cofactor HCF-1 and associated hSet1/MLL histone H3 lysine 4 methyltransferase complex, facilitating the activation of genes required for proliferation.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • E2F Transcription Factors / genetics
  • E2F Transcription Factors / metabolism
  • Host Cell Factor C1 / genetics
  • Host Cell Factor C1 / metabolism
  • Humans
  • Models, Biological
  • S Phase / genetics
  • S Phase / physiology*

Substances

  • E2F Transcription Factors
  • HCFC1 protein, human
  • Host Cell Factor C1