Abstract
In a recent issue of Molecular Cell, Tyagi et al. (2007) show that E2F1, a positive regulator of S phase entry, recruits cofactor HCF-1 and associated hSet1/MLL histone H3 lysine 4 methyltransferase complex, facilitating the activation of genes required for proliferation.
MeSH terms
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Animals
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E2F Transcription Factors / genetics
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E2F Transcription Factors / metabolism
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Host Cell Factor C1 / genetics
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Host Cell Factor C1 / metabolism
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Humans
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Models, Biological
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S Phase / genetics
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S Phase / physiology*
Substances
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E2F Transcription Factors
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HCFC1 protein, human
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Host Cell Factor C1