Alteration of DNA synthesis in human brain tumor cells by gallium nitrate in vitro

Pediatr Neurol. 1991 Sep-Oct;7(5):352-4. doi: 10.1016/0887-8994(91)90065-s.

Abstract

We measured 3H-thymidine incorporation by human brain tumor cell lines treated with varying doses of gallium nitrate. These DNA synthesis data indicate that the effects of gallium documented for brain tumor cell viability parallel those for alterations in DNA synthesis. The primitive, poorly-differentiated, small, round-cell tumors (medulloblastoma and rhabdomyosarcoma) appear to be more sensitive than glially differentiated neoplasms (glioblastoma) to DNA synthesis inhibition by gallium nitrate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / pathology
  • Cell Division / drug effects
  • DNA, Neoplasm / biosynthesis*
  • Gallium / pharmacology*
  • Glioma / metabolism*
  • Glioma / pathology
  • Humans
  • Medulloblastoma / metabolism*
  • Medulloblastoma / pathology
  • Rhabdomyosarcoma / metabolism*
  • Rhabdomyosarcoma / pathology
  • Thymidine
  • Time Factors
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / metabolism

Substances

  • Antineoplastic Agents
  • DNA, Neoplasm
  • Gallium
  • Thymidine
  • gallium nitrate