A novel model for an older remodeler: the BAF swap in neurogenesis

Stefan Aigner; Ahmet M Denli; Fred H Gage

doi:10.1016/j.neuron.2007.07.004

A novel model for an older remodeler: the BAF swap in neurogenesis

Neuron. 2007 Jul 19;55(2):171-3. doi: 10.1016/j.neuron.2007.07.004.

Authors

Stefan Aigner¹, Ahmet M Denli, Fred H Gage

Affiliation

¹ Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

PMID: 17640518
DOI: 10.1016/j.neuron.2007.07.004

Abstract

Changes in chromatin state contribute to the switch in gene expression programs that characterizes the transition of dividing neural stem cells toward a neuronal fate. In this issue of Neuron, Lessard et al. show that this process is regulated by specific cofactor exchanges within the SWI/SNF chromatin remodeling complex.

Publication types

Comment

MeSH terms

Animals
Cell Differentiation / physiology*
Chromatin / metabolism*
Gene Expression Regulation, Developmental / physiology
Histones / metabolism
Humans
Multienzyme Complexes / metabolism
Neurons / cytology*
Neurons / physiology
Stem Cells / metabolism*
Transcription Factors / metabolism*
Transcription, Genetic / physiology

Substances

Chromatin
Histones
Multienzyme Complexes
Transcription Factors