Abstract
Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (= (+)-catechin-(4-->8)-(-)-epicatechin) (1) and (+)-catechin-(4-->8)-(+)-catechin-(4-->8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5+/-2.3 and 21.9+/-2.2 nM, resp.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA Topoisomerases, Type II / metabolism
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Fabaceae / enzymology*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Stems / enzymology*
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Topoisomerase II Inhibitors*
Substances
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Enzyme Inhibitors
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Plant Extracts
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Topoisomerase II Inhibitors
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DNA Topoisomerases, Type II