Topoisomerase-II-inhibitory principles from the stems of Spatholobus suberectus

Chem Biodivers. 2007 Jul;4(7):1487-91. doi: 10.1002/cbdv.200790127.

Abstract

Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (= (+)-catechin-(4-->8)-(-)-epicatechin) (1) and (+)-catechin-(4-->8)-(+)-catechin-(4-->8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5+/-2.3 and 21.9+/-2.2 nM, resp.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Topoisomerases, Type II / metabolism
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology
  • Fabaceae / enzymology*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Stems / enzymology*
  • Topoisomerase II Inhibitors*

Substances

  • Enzyme Inhibitors
  • Plant Extracts
  • Topoisomerase II Inhibitors
  • DNA Topoisomerases, Type II