Abstract
We describe 24 Ugandan patients with human immunodeficiency virus infection who developed symptomatic hyperlactatemia associated with the use of nucleoside analogues. All patients were receiving combination therapy that contained stavudine. The median serum lactate level was 6.6 mmol/L. All patients had their antiretroviral treatment regimen discontinued. Hospital admission was required for 5 patients. Five patients died.
MeSH terms
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Acidosis, Lactic / chemically induced*
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Acidosis, Lactic / complications
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Acidosis, Lactic / diagnosis
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Adult
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / therapeutic use
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Female
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HIV Infections / complications*
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HIV Infections / drug therapy
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Humans
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Lactic Acid / blood*
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Lamivudine / adverse effects
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Lamivudine / therapeutic use
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Male
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Middle Aged
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Nevirapine / adverse effects
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Nevirapine / therapeutic use
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Reverse Transcriptase Inhibitors / adverse effects*
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Reverse Transcriptase Inhibitors / therapeutic use
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Stavudine / adverse effects
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Stavudine / therapeutic use
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Uganda
Substances
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Anti-HIV Agents
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Reverse Transcriptase Inhibitors
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Lamivudine
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Lactic Acid
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Nevirapine
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Stavudine