Mitotic motors: kinesin-5 takes a brake

Curr Biol. 2007 Jul 17;17(14):R544-7. doi: 10.1016/j.cub.2007.05.030.

Abstract

A kinesin-5-dependent 'sliding filament' mechanism is commonly used to actively push apart the poles during mitotic spindle assembly and elongation, but a recent study now shows that, in C. elegans, kinesin-5 is deployed as a brake to slow down spindle-pole separation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / physiology*
  • Kinesins / physiology*
  • Mitosis / physiology*
  • Spindle Apparatus / physiology*

Substances

  • Kinesins