The objective of this study was to retrospectively investigate the surgical indications, operation methods, and postoperative results of patients with cavernous malformations (CMs) and the use of neuronavigation. Seventy patients with CMs were operated on in our hospital. The initial symptoms were hemorrhage in 31 cases, seizures in 29 cases, focal neurological deficit in 4 cases, and headache in 5 cases. Only one asymptomatic case was incidentally identified by radiological examination. The size of CMs ranged from 5 to 50 mm (mean: 21 mm). The CMs in 39 patients were located within the white matter of the hemispheres, 11 within the basal ganglia or thalamus, 5 within the cerebellum, and 6 in multiple locations. Prior to the operation, five fiducial markers were placed on the scalp and magnetic resonance imaging (MRI) was performed. Data were transferred to the neuronavigation workstation, a profile of tumors was drawn up, and a three-dimensional reconstruction was completed. The foci were separated and resected under a microscope through a sulci and fissures approach. All the lesions were resected totally. No residual foci were found by postoperative computed tomography (CT)/MRI examination, and there was no operative death. The disability rate was 8.6%; four patients had a new transitory neurological deficit within 1 month after the operation, and one patient with thalamic CMs developed facial paralysis. All patients, however, recovered in 6 months. Twenty-four patients with preoperative epilepsy were followed up for 6-24 months (mean: 19.4 months). After the operation, seizures disappeared in 19 patients and symptoms improved in 5. CMs can be determined in patients even if patients are asymptomatic. Surgical treatment should be considered if bleeding occurs. An operation with the guidance of neuronavigation is safe and can decrease the occurrence of disability following the procedure.