Implementation validation performed in Rwanda to determine whether the INNO-LiPA Rif.TB line probe assay can be used for detection of multidrug-resistant Mycobacterium tuberculosis in low-resource countries

Cindy Maria Quezada; Eliane Kamanzi; Julienne Mukamutara; Pim De Rijk; Leen Rigouts; Françoise Portaels; Yanis Ben Amor

doi:10.1128/JCM.00590-07

Implementation validation performed in Rwanda to determine whether the INNO-LiPA Rif.TB line probe assay can be used for detection of multidrug-resistant Mycobacterium tuberculosis in low-resource countries

J Clin Microbiol. 2007 Sep;45(9):3111-4. doi: 10.1128/JCM.00590-07. Epub 2007 Jul 11.

Authors

Cindy Maria Quezada¹, Eliane Kamanzi, Julienne Mukamutara, Pim De Rijk, Leen Rigouts, Françoise Portaels, Yanis Ben Amor

Affiliation

¹ Laboratory of Structural Microbiology, Rockefeller University, New York, NY, USA.

Abstract

We validated the implementation of the INNO-LiPA Rif.TB line probe assay, a diagnostic test for rapid detection of multidrug-resistant tuberculosis (MDR-TB), in Rwanda. No substantial difference was found between results obtained in Rwanda and results obtained in Belgium with the same samples. This rapid diagnostic test for MDR-TB can therefore be reliably implemented in a resource-poor setting.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Validation Study

MeSH terms

Bacteriological Techniques / methods*
Belgium
Humans
Molecular Diagnostic Techniques / methods*
Mycobacterium tuberculosis / genetics
Mycobacterium tuberculosis / isolation & purification*
Rwanda
Tuberculosis, Multidrug-Resistant / diagnosis*
Tuberculosis, Multidrug-Resistant / microbiology*