Abstract
We sought to determine if Chamorro individuals with a family history of Guam dementia (GD) or Parkinson dementia complex (PDC) exhibit presymptomatic brain MRI changes. Sixty-six Chamorro subjects had neurocognitive assessment and volumetric MRI. MRI brain volumes differed between diagnostic groups (GD, PDC, control) and according to family history. Chamorros with a family history of PDC or dementia may have increased brain atrophy, suggesting a hereditary susceptibility to neurodegenerative disorders.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Age Factors
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Aged
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Aged, 80 and over
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Aging / pathology*
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Amyotrophic Lateral Sclerosis / ethnology
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Amyotrophic Lateral Sclerosis / pathology*
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Amyotrophic Lateral Sclerosis / physiopathology
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Atrophy / ethnology
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Atrophy / pathology
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Atrophy / physiopathology
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Brain / pathology*
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Cohort Studies
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Dementia / ethnology
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Dementia / pathology*
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Dementia / physiopathology
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Disease Progression
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Female
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Guam / ethnology
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Humans
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Parkinsonian Disorders / ethnology
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Parkinsonian Disorders / pathology*
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Parkinsonian Disorders / physiopathology
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Predictive Value of Tests
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Prognosis