In vivo activity of a novel polymeric guanidine in experimental skin infection with methicillin-resistant Staphylococcus aureus

Christina Kratzer; Selma Tobudic; Karin Macfelda; Wolfgang Graninger; Apostolos Georgopoulos

doi:10.1128/AAC.00130-07

In vivo activity of a novel polymeric guanidine in experimental skin infection with methicillin-resistant Staphylococcus aureus

Antimicrob Agents Chemother. 2007 Sep;51(9):3437-9. doi: 10.1128/AAC.00130-07. Epub 2007 Jul 9.

Authors

Christina Kratzer¹, Selma Tobudic, Karin Macfelda, Wolfgang Graninger, Apostolos Georgopoulos

Affiliation

¹ Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Abstract

The in vivo efficacy of the novel polymeric guanidine AKACID Plus was evaluated in a guinea pig model of experimental skin infection with methicillin-resistant Staphylococcus aureus (MRSA). Topical application of AKACID Plus at concentrations of > or =0.5% was as effective as mupirocin 2% cream in the treatment of superficial skin infection with MRSA.

MeSH terms

Animals
Anti-Bacterial Agents / therapeutic use*
Colony Count, Microbial
Dose-Response Relationship, Drug
Female
Guanidines / therapeutic use*
Guinea Pigs
Male
Methicillin Resistance
Mupirocin / pharmacology
Polymers / therapeutic use*
Skin / microbiology
Skin Diseases, Infectious / drug therapy*
Staphylococcal Infections / drug therapy*
Staphylococcal Infections / microbiology

Substances

AKACID Plus
Anti-Bacterial Agents
Guanidines
Polymers
Mupirocin