Lepidepyrone, a new gamma-pyrone derivative, from Neolentinus lepideus, inhibits hyaluronidase

J Antibiot (Tokyo). 2007 Jun;60(6):388-90. doi: 10.1038/ja.2007.53.

Abstract

In the course of screening for hyaluronidase (HAase) inhibitory agents, a new gamma-pyrone derivative, lepidepyrone, C(8)H(10)O(5), was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound (IC(50) 3.3 mM). The structure of lepidepyrone was established on the basis of spectroscopic investigation.

MeSH terms

  • Basidiomycota / chemistry*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / pharmacology
  • Hyaluronoglucosaminidase / antagonists & inhibitors*
  • Hyaluronoglucosaminidase / metabolism
  • Inhibitory Concentration 50
  • Mass Spectrometry
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Pyrones / chemistry
  • Pyrones / isolation & purification*
  • Pyrones / metabolism
  • Pyrones / pharmacology
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Enzyme Inhibitors
  • Pyrones
  • Hyaluronoglucosaminidase