Abstract
In the course of screening for hyaluronidase (HAase) inhibitory agents, a new gamma-pyrone derivative, lepidepyrone, C(8)H(10)O(5), was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound (IC(50) 3.3 mM). The structure of lepidepyrone was established on the basis of spectroscopic investigation.
MeSH terms
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Basidiomycota / chemistry*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology
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Hyaluronoglucosaminidase / antagonists & inhibitors*
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Hyaluronoglucosaminidase / metabolism
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Inhibitory Concentration 50
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Mass Spectrometry
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / metabolism
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Pyrones / pharmacology
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Enzyme Inhibitors
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Pyrones
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Hyaluronoglucosaminidase