This paper describes the development of artificial neural network (ANN) based carbon monoxide (CO) persistence (ANNCOP) models to forecast 8-h average CO concentration using 1-h maximum predicted CO data for the critical (winter) period (November-March). The models have been developed for three 8-h groupings of 10 P.M. to 6 A.M., 6 A.M., to 2 P.M. and 2-10 P.M., at two air quality control regions (AQCRs) in Delhi city, representing an urban intersection and an arterial road consisting heterogeneous traffic flows. The result indicates that time grouping of 2-10 PM is dominantly affected by inversion conditions and peak traffic flow. The ANNCOP model corresponding to this grouping predicts the 8-h average CO concentrations within the accuracy range of 68-71%. The CO persistence values derived from ANNCOP model are comparable with the persistence values as suggested by the Environmental Protection Agency (EPA), USA. This work demonstrates that ANN based model is capable of describing winter period CO persistence phenomena.