Kaposi's sarcoma is a frequently seen AIDS-related malignant neoplasm in the head and neck region, especially in the oral cavity, but is rarely described in the HIV-negative and non-immunosuppressed individual. The case of a 76-year-old HIV-negative, non-immunocompromised woman with a solitary Kaposi's sarcoma of the tongue is reported. The tumour was locally excised with subsequent local radiotherapy. Diagnosis and therapy are discussed and compared with a review of the contemporary literature.