Inhibition of human lipoprotein oxidation by morelloflavone and camboginol from Garcinia dulcis

Nat Prod Res. 2007 Jun;21(7):655-62. doi: 10.1080/14786410701371256.

Abstract

A biflavonoids, morelloflavone (1) and a prenyltated xanthone, camboginol (2), isolated from the fruits of Garcinia dulcis (Roxb.) Kurz., exhibited strong antioxidation effects in both Fe2+ -mediated and non-metal induced human low-density lipoprotein (LDL) oxidations. However, a well-known antioxidant, alpha-tocopherol (vitamin E), was found less potent than both compounds based on the same test systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Biflavonoids / chemistry
  • Biflavonoids / isolation & purification
  • Biflavonoids / pharmacology*
  • Ferrous Compounds / chemistry
  • Fruit / chemistry
  • Garcinia / chemistry*
  • Humans
  • Lipoproteins, LDL / metabolism*
  • Oxidation-Reduction / drug effects
  • Terpenes / chemistry
  • Terpenes / isolation & purification
  • Terpenes / pharmacology*
  • Thailand
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Antioxidants
  • Biflavonoids
  • Ferrous Compounds
  • Lipoproteins, LDL
  • Terpenes
  • Thiobarbituric Acid Reactive Substances
  • morelloflavone
  • ferrous sulfate
  • garcinol