Variations on RNA folding and alignment: lessons from Benasque

J Math Biol. 2008 Jan;56(1-2):129-44. doi: 10.1007/s00285-007-0107-5. Epub 2007 Jul 5.

Abstract

Dynamic programming algorithms solve many standard problems of RNA bioinformatics in polynomial time. In this contribution we discuss a series of variations on these standard methods that implement refined biophysical models, such as a restriction of RNA folding to canonical structures, and an extension of structural alignments to an explicit scoring of stacking propensities. Furthermore, we demonstrate that a local structural alignment can be employed for ncRNA gene finding. In this context we discuss scanning variants for folding and alignment algorithms.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Computational Biology / methods*
  • Nucleic Acid Conformation*
  • RNA, Untranslated / chemistry*
  • RNA, Untranslated / genetics*
  • Sequence Alignment

Substances

  • RNA, Untranslated