A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery

Suzanne J Dilly; Matthew J Bell; Andrew J Clark; Andrew Marsh; Richard M Napier; Martin J Sergeant; Andrew J Thompson; Paul C Taylor

doi:10.1039/b704271j

A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery

Chem Commun (Camb). 2007 Jul 19:(27):2808-10. doi: 10.1039/b704271j. Epub 2007 Jun 12.

Authors

Suzanne J Dilly¹, Matthew J Bell, Andrew J Clark, Andrew Marsh, Richard M Napier, Martin J Sergeant, Andrew J Thompson, Paul C Taylor

Affiliation

¹ Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.

PMID: 17609783
DOI: 10.1039/b704271j

Abstract

We show that the use of multiple photochemistries is necessary to ensure diverse immobilisation of small molecules for binding of polypeptides using phage display and antibody libraries.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Design*
Peptide Library
Peptides / metabolism
Photochemistry

Substances

Peptide Library
Peptides