Abstract
The synthesis of a variety of arabinose derivatives that have been modified at C-5 was achieved from d-arabinose. The 5-fluoro and 5-methoxy compounds were converted into the corresponding farnesyl phosphodiesters as putative chain terminators of mycobacterial arabinan biosynthesis. Biological testing of these materials revealed no effective anti-mycobacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / chemistry
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Arabinose / analogs & derivatives*
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Arabinose / chemical synthesis
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Arabinose / chemistry
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Mycobacterium / enzymology
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Pentosyltransferases / antagonists & inhibitors
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Polysaccharides / biosynthesis*
Substances
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Antitubercular Agents
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Polysaccharides
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arabinofuranose
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araban
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Arabinose
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Pentosyltransferases
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arabinosyltransferase