Production of optically active 1,2,4-butanetriol from corresponding racemate by Microbial stereoinversion

J Biosci Bioeng. 2007 May;103(5):494-6. doi: 10.1263/jbb.103.494.

Abstract

Sterigmatomyces elviae DSM 70852 produced 12 g/l (S)-1,2,4-butanetriol (enantiomeric excess >99.9%) from 20 g/l racemate in 82 h. From the results of the inversion of an (R)-isomer to an (S)-isomer and GC-MS, it was suggested that (R)-1,2,4-butanetriol is oxidized to 1,4-dihydroxy-2-butanone, which is reduced to an (S)-isomer.

MeSH terms

  • Butanols / chemistry*
  • Butanols / isolation & purification*
  • Oxidation-Reduction
  • Stereoisomerism
  • Streptomyces / metabolism*

Substances

  • Butanols
  • 1,3,4-butanetriol