Synthesis of 2,3-dihydro-10bh-oxazolo[2,3-a]isoquinolines from ortho-lithiated phenyloxazolinyloxiranes

Vito Capriati; Saverio Florio; Renzo Luisi; Filippo Maria Perna

doi:10.1021/jo070708x

Synthesis of 2,3-dihydro-10bh-oxazolo[2,3-a]isoquinolines from ortho-lithiated phenyloxazolinyloxiranes

J Org Chem. 2007 Aug 3;72(16):6316-9. doi: 10.1021/jo070708x. Epub 2007 Jul 4.

Authors

Vito Capriati¹, Saverio Florio, Renzo Luisi, Filippo Maria Perna

Affiliation

¹ Dipartimento Farmaco-Chimico, Università di Bari, C.N.R., Istituto di Chimica dei Composti OrganoMetallici, Sezione di Bari, Via E. Orabona 4, I-70125 Bari, Italy.

PMID: 17608536
DOI: 10.1021/jo070708x

Abstract

A general method for the synthesis of 2,3-dihydro-10bH-oxazolo[2,3-a]isoquinolines from the reaction of (R*,R*)-configured ortho-bromophenyloxazolinyloxiranes and organolithiums is described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkanes / chemistry
Chemistry, Organic / methods*
Ethylene Oxide / chemical synthesis*
Ethylene Oxide / chemistry*
Isoquinolines / chemical synthesis*
Isoquinolines / chemistry*
Lithium / chemistry
Magnetic Resonance Spectroscopy
Models, Chemical
Oxazoles / chemical synthesis*
Oxazoles / chemistry*

Substances

Alkanes
Isoquinolines
Oxazoles
Lithium
Ethylene Oxide