[Meta-analysis on the association of Myocilin Q368X mutation and primary open angle glaucoma]

Zhonghua Yan Ke Za Zhi. 2007 Apr;43(4):361-6.
[Article in Chinese]

Abstract

Objective: To study the association between Myocilin (MYOC) Gln368STOP mutation and primary open angle glaucoma (POAG) by means of Meta-analysis.

Methods: Odds ratios (OR) of MYOC Gln368STOP genotype distributions in POAG patients verse the controls were analyzed. All the relevant reported studies were identified. Poor-qualified studies were eliminated, and the risk of publication bias was excluded. Meta-analysis software, RevMan 4.2, was applied for investigating heterogeneity among individual studies and summarizing the effects across studies.

Results: A total of 3077 POAG cases and 2063 controls from 11 studies were included. No heterogeneity among these studies was noticed (P = 0.79). The pooled OR (with 95% CI) of MYOC Gln368STOP in POAG cases versus that in the controls was 6.01 (2.57 - 14.04, P < 0.01).

Conclusion: MYOC Gln368STOP mutation might be associated with the increased risk of POAG and is one of its risk factors.

Publication types

  • English Abstract
  • Meta-Analysis

MeSH terms

  • Cytoskeletal Proteins / genetics*
  • Eye Proteins / genetics*
  • Genotype
  • Glaucoma, Open-Angle / genetics*
  • Glycoproteins / genetics*
  • Humans
  • Mutation*

Substances

  • Cytoskeletal Proteins
  • Eye Proteins
  • Glycoproteins
  • trabecular meshwork-induced glucocorticoid response protein