Coccidioidomycosis, also known as San Joaquin Valley Fever, is an endemic mycosis restricted to the American deserts, caused by the ascomycete Coccidioides spp. In 2000 it was estimated that more than 100,000 cases of the disease took place in the United States, and that these numbers have been rising over time. The current impact of this disease in Mexico is unknown, but the available data suggest that an increase of the incidence of this mycosis in California and Arizona might have the same impact in Mexican nearby States. These two USA States both have a bioclimatic pattern similar to the nearby Mexican States endemic for coccidioidomycosis. The main objective of this study was to collect the available information on the historical and epidemiological research done in Mexico to assess the impact of the disease and to evaluate whether the disease have a tendency to increase in the endemic areas and if this grow could represent a problem of public health in Mexico. We have conducted an extensive search on this topic in Health institutions and Academic facilities of California, Arizona and Mexico. After analyzing the scarce Mexican records we found that: 1) the main studies conducted in Mexico are limited to the northern desert areas of the country, mainly in the states of Sonora, Coahuila, Nuevo Leon and the Baja California peninsula; 2) until 1994 an increase of coccidioidomycosis in Mexico was noted; and 3) we found that Mexico shares a similar epidemiological data as that reported in the United States. For instance, the most affected groups in Mexico were children under 5 years-old and adults over 45 years-old. The collective information suggests the need to implement joined organized efforts and multi-institutional collaboration to clarify the current situation of this important endemic disease of North America to administer a viable early detection plan of this mycosis in Mexico.