Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex

G A Romanova; D N Silachev; F M Shakova; Yu N Kvashennikova; I V Viktorov; S I Shram; N F Myasoedov

doi:10.1007/s10517-006-0445-0

Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex

Bull Exp Biol Med. 2006 Dec;142(6):663-6. doi: 10.1007/s10517-006-0445-0.

[Article in English, Russian]

Authors

G A Romanova¹, D N Silachev, F M Shakova, Yu N Kvashennikova, I V Viktorov, S I Shram, N F Myasoedov

Affiliation

¹ Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. romanovaga@mail.ru

PMID: 17603664
DOI: 10.1007/s10517-006-0445-0

Abstract

Semax had a pronounced neuroprotective and antiamnesic effect during focal photoinduced ischemia of the prefrontal cortex. Intranasal administration of Semax for 6 days decreased the volume of cortical infarction and improved retention and performance of conditioned passive avoidance response.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Intranasal
Adrenocorticotropic Hormone / administration & dosage
Adrenocorticotropic Hormone / analogs & derivatives*
Adrenocorticotropic Hormone / pharmacology
Amnesia / drug therapy*
Animals
Animals, Outbred Strains
Brain Infarction / etiology
Brain Infarction / pathology*
Brain Infarction / prevention & control*
Cerebral Cortex / drug effects*
Cerebral Cortex / pathology
Ischemic Attack, Transient / complications
Male
Neuroprotective Agents / administration & dosage
Neuroprotective Agents / pharmacology*
Peptide Fragments / administration & dosage
Peptide Fragments / pharmacology*
Rats
Treatment Outcome

Substances

Neuroprotective Agents
Peptide Fragments
ACTH (4-7), Pro-Gly-Pro-
Adrenocorticotropic Hormone