Abstract
Total synthesis of (-)-agelastatin A has been achieved starting from l-arabitol. The highlights in our synthesis include the preparation of vicinal diamine moiety by [3.3] sigmatropic rearrangement of allyl cyanate and construction of central ring-C with ring-closing metathesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry
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Allyl Compounds / chemistry*
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Catalysis
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Cyanates / chemistry*
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Molecular Structure
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Oxazolidinones / chemical synthesis*
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Oxazolidinones / chemistry
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Stereoisomerism
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Sugar Alcohols / chemistry*
Substances
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Alkaloids
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Allyl Compounds
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Cyanates
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Oxazolidinones
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Sugar Alcohols
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agelastatin A
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arabitol