Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe

Elmi N Zainuddin; Renate Mentel; Victor Wray; Rolf Jansen; Manfred Nimtz; Michael Lalk; Sabine Mundt

doi:10.1021/np060303s

Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe

J Nat Prod. 2007 Jul;70(7):1084-8. doi: 10.1021/np060303s. Epub 2007 Jun 28.

Authors

Elmi N Zainuddin¹, Renate Mentel, Victor Wray, Rolf Jansen, Manfred Nimtz, Michael Lalk, Sabine Mundt

Affiliation

¹ Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.

PMID: 17602586
DOI: 10.1021/np060303s

Abstract

Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemistry
Antiviral Agents / isolation & purification*
Antiviral Agents / pharmacology
Depsipeptides / chemistry
Depsipeptides / isolation & purification*
Depsipeptides / pharmacology
Germany
Influenza A virus / drug effects*
Inhibitory Concentration 50
Microcystis / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Antiviral Agents
Depsipeptides
ichthyopeptin A
ichthyopeptin B