The objective of this work was to investigate the interactions between the level of concentrations of Ca, V Cr, Mn, Fe, Ni, Cu, Zn, As and Pb in potable water, soil, vegetation and school children hair and disease incidences of neoplasms, diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, endocrine, nutritional and metabolic diseases, mental and behavioral disorders and diseases of the circulatory system on the population groups which are homogeneously exposed to the environmental conditions. It was found that potable water among the other investigated aspects of the physical environment has the greatest impact on the public health. The environment-disease incidence interactions have been found for all investigated diseases groups. The results reported here emphasize the importance of the observation of the mutual effects of the environmental variables on the human health for the identification of their synergetic as well as antagonistic effects.