Abstract
Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / metabolism
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Cardiomyopathies / epidemiology
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Cardiomyopathies / etiology*
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Cardiomyopathies / physiopathology
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Cardiomyopathies / prevention & control
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Diabetes Complications / epidemiology
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Diabetes Complications / physiopathology*
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Diabetes Complications / prevention & control
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Diabetes Mellitus, Experimental / complications
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Diabetes Mellitus, Experimental / physiopathology
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Diastole
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Fatty Acids, Nonesterified / metabolism
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Heart Failure / epidemiology
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Heart Failure / etiology
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Heart Failure / physiopathology
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Heart Failure / prevention & control
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Homeostasis
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Humans
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Mice
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Mice, Mutant Strains
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Mitochondria, Heart / physiology
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Models, Animal
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Oxidative Stress
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PPAR alpha / metabolism
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Rats
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Rats, Zucker
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Renin-Angiotensin System / physiology
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Ventricular Dysfunction, Left / etiology
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Ventricular Dysfunction, Left / physiopathology
Substances
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Fatty Acids, Nonesterified
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PPAR alpha
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Calcium