New 4-methylated and 19-oxygenated steroids from the Formosan soft coral Nephthea erecta

Shi-Yie Cheng; Chang-Feng Dai; Chang-Yih Duh

doi:10.1016/j.steroids.2007.05.001

New 4-methylated and 19-oxygenated steroids from the Formosan soft coral Nephthea erecta

Steroids. 2007 Jul;72(8):653-9. doi: 10.1016/j.steroids.2007.05.001. Epub 2007 May 17.

Authors

Shi-Yie Cheng¹, Chang-Feng Dai, Chang-Yih Duh

Affiliation

¹ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.

PMID: 17585977
DOI: 10.1016/j.steroids.2007.05.001

Abstract

Two new 4-methylated steroids, erectasteroids A and B (1 and 2), six new 19-oxygenated steroids, erectasteroids C-H (3-8) and two known 19-oxygenated steroids (9 and 10) were isolated from the acetone solubles of the Formosan soft coral Nephthea erecta. The structures were elucidated by extensive NMR spectroscopic analysis and their cytotoxicity against selected cancer cells was measured in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Leukemia P388 / drug therapy
Magnetic Resonance Spectroscopy
Molecular Conformation
Molecular Structure
Steroids / chemistry*
Steroids / isolation & purification
Steroids / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Steroids