Lignans, an amide and anti-platelet activities from Piper philippinum

Yu-Chang Chen; Chang-Hui Liao; Ih-Sheng Chen

doi:10.1016/j.phytochem.2007.05.003

Lignans, an amide and anti-platelet activities from Piper philippinum

Phytochemistry. 2007 Aug;68(15):2101-11. doi: 10.1016/j.phytochem.2007.05.003. Epub 2007 Jun 21.

Authors

Yu-Chang Chen¹, Chang-Hui Liao, Ih-Sheng Chen

Affiliation

¹ Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.

PMID: 17585974
DOI: 10.1016/j.phytochem.2007.05.003

Abstract

Investigation of the stem extract of Piper philippinum led to isolation of eight compounds, piperphilippinins I-VI (1-6), philippinamide (7), and (+)-bornyl caffeate (8), together with 26 known compounds. Among the isolates, (-)-3',4'-O,O-demethylenehinokinin (10) and 3,4-methylenedioxycinnamaldehyde (23) showed anti-platelet activities in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides* / isolation & purification
Amides* / pharmacology
Animals
Blood Platelets / drug effects
In Vitro Techniques
Lignans* / isolation & purification
Lignans* / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Piper / chemistry*
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plant Stems / chemistry
Platelet Aggregation Inhibitors* / isolation & purification
Platelet Aggregation Inhibitors* / pharmacology
Rabbits

Substances

Amides
Lignans
Plant Extracts
Platelet Aggregation Inhibitors