Comparison of Ru- and Mo-based chiral olefin metathesis catalysts. Complementarity in asymmetric ring-opening/cross-metathesis reactions of oxa- and azabicycles

G Alex Cortez; Carl A Baxter; Richard R Schrock; Amir H Hoveyda

doi:10.1021/ol071008h

Comparison of Ru- and Mo-based chiral olefin metathesis catalysts. Complementarity in asymmetric ring-opening/cross-metathesis reactions of oxa- and azabicycles

Org Lett. 2007 Jul 19;9(15):2871-4. doi: 10.1021/ol071008h. Epub 2007 Jun 22.

Authors

G Alex Cortez¹, Carl A Baxter, Richard R Schrock, Amir H Hoveyda

Affiliation

¹ Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.

PMID: 17585770
DOI: 10.1021/ol071008h

Abstract

A comparative study of chiral Mo- and Ru-based catalysts to promote enantioselective synthesis of 2,6-disubstituted pyrans and piperidines through asymmetric ring-opening/cross-metathesis (AROM/CM) reactions is presented. These studies demonstrate the critical complementarity that exists between the two classes of chiral catalysts.

Publication types

Comparative Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alkenes / chemistry*
Bridged Bicyclo Compounds / chemistry*
Catalysis
Molybdenum / chemistry*
Ruthenium / chemistry*
Stereoisomerism

Substances

Alkenes
Bridged Bicyclo Compounds
Ruthenium
Molybdenum

Abstract

Publication types

MeSH terms

Substances

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