Case of localized bullous pemphigoid with unique clinical manifestations in the lower legs

J Dermatol. 2007 Jul;34(7):482-5. doi: 10.1111/j.1346-8138.2007.00315.x.

Abstract

We report the case of a 71-year-old Japanese woman who presented with persistent band-like erosions in the lower legs. Histological examination suggested subepidermal blister formation. Direct and indirect immunofluorescence studies revealed tissue-deposited and circulating immunoglobulin G autoantibodies against the basement membrane. Western blotting revealed autoantibodies to BP230, but not to BP180. Based on these findings, the patient was diagnosed as having a localized type of bullous pemphigoid. We suggest that the unique clinical manifestations in this patient could be attributable to bacterial or fungal infection, and/or mechanical trauma, such as the pressure of her socks.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autoantibodies / blood
  • Female
  • Humans
  • Immunologic Tests
  • Leg / pathology*
  • Pemphigoid, Bullous / immunology
  • Pemphigoid, Bullous / pathology*
  • Skin / immunology
  • Skin / pathology*

Substances

  • Autoantibodies