Synthesis and antihypertensive effects of new methylthiomorpholinphenol derivatives

A Ma Velázquez; L Martínez; V Abrego; M A Balboa; L A Torres; B Camacho; S Díaz-Barriga; A Romero; R López-Castañares; E Angeles

doi:10.1016/j.ejmech.2007.04.003

Synthesis and antihypertensive effects of new methylthiomorpholinphenol derivatives

Eur J Med Chem. 2008 Mar;43(3):486-500. doi: 10.1016/j.ejmech.2007.04.003. Epub 2007 Apr 25.

Authors

A Ma Velázquez¹, L Martínez, V Abrego, M A Balboa, L A Torres, B Camacho, S Díaz-Barriga, A Romero, R López-Castañares, E Angeles

Affiliation

¹ División de Ciencias Químico Biológicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54740 Cuautitlán Izcalli, Estado de México, Mexico.

PMID: 17582658
DOI: 10.1016/j.ejmech.2007.04.003

Abstract

We present in this work the synthesis and cardiovascular effects of new methylthiomorpholine compounds and they were compared with cardiovascular drugs such as captopril, losartan and omapatrilat.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antihypertensive Agents / chemical synthesis*
Antihypertensive Agents / chemistry
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Drug Design
Heart Rate / drug effects
Morpholines / chemical synthesis*
Morpholines / chemistry
Morpholines / pharmacology*
Phenols / chemical synthesis*
Phenols / chemistry
Phenols / pharmacology*
Rats

Substances

Antihypertensive Agents
Morpholines
Phenols