Leukocyte podosomes sense their way through the endothelium

Andrés Hidalgo; Paul S Frenette

doi:10.1016/j.immuni.2007.06.002

Leukocyte podosomes sense their way through the endothelium

Immunity. 2007 Jun;26(6):753-5. doi: 10.1016/j.immuni.2007.06.002.

Authors

Andrés Hidalgo¹, Paul S Frenette

Affiliation

¹ Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

PMID: 17582348
DOI: 10.1016/j.immuni.2007.06.002

Abstract

Whether leukocytes can transmigrate through endothelial cells, rather than between them, is controversial. In this issue, Carman et al. (2007) demonstrate that lymphocytes can extend podosomes to palpate endothelial cells searching for areas permissive for transcellular diapedesis.

Publication types

Comment

MeSH terms

Cell Movement*
Endothelium, Vascular / immunology*
Humans
Leukocytes / immunology*