Diarylprolinol silyl ether as catalyst of an exo-selective, enantioselective Diels-Alder reaction

Hiroaki Gotoh; Yujiro Hayashi

doi:10.1021/ol071009+

Diarylprolinol silyl ether as catalyst of an exo-selective, enantioselective Diels-Alder reaction

Org Lett. 2007 Jul 19;9(15):2859-62. doi: 10.1021/ol071009+. Epub 2007 Jun 20.

Authors

Hiroaki Gotoh¹, Yujiro Hayashi

Affiliation

¹ Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.

PMID: 17580885
DOI: 10.1021/ol071009+

Abstract

In combined use with CF3CO2H, 2-[bis(3,5-bis-trifluoromethylphenyl) triethylsiloxymethyl]pyrrolidine was found to be an effective organocatalyst of an exo-selective, enantioselective Diels-Alder reaction of alpha,beta-unsaturated aldehydes.