Natural antioxidant compounds in risk factors for CVD

Pharmacol Res. 2007 Aug;56(2):99-109. doi: 10.1016/j.phrs.2007.04.018. Epub 2007 May 10.

Abstract

The benefits of drug treating hypertension, hyperglycemia and hyperlipidemias in terms of reduction of CVD morbidity and mortality are well established. However, there is epidemiological evidence that consumption of certain foods results to a reduction in myocardial infarction markers. Given in many reviews is the impact of dietary antioxidants pertained to LDL oxidation and to vascular endothelial dysfunction. The potential of a diet rich in these compounds on the management of hypertension, hyperglycemia and hyperlipidemias is hereby criticized. Although their clinical use not always translates into clinical benefit, data are motivating. In the future, these agents may be very important complementary treatment options for subjects with high risk for CVD.

Publication types

  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use*
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular Diseases / prevention & control*
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiopathology
  • Humans
  • Hyperglycemia / complications
  • Hyperglycemia / drug therapy*
  • Hyperglycemia / metabolism
  • Hyperglycemia / physiopathology
  • Hyperlipidemias / complications
  • Hyperlipidemias / drug therapy*
  • Hyperlipidemias / metabolism
  • Hyperlipidemias / physiopathology
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Hypertension / metabolism
  • Hypertension / physiopathology
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use*
  • Hypolipidemic Agents / pharmacology
  • Hypolipidemic Agents / therapeutic use*
  • Oxidative Stress / drug effects
  • Risk Factors
  • Treatment Outcome

Substances

  • Antihypertensive Agents
  • Antioxidants
  • Hypoglycemic Agents
  • Hypolipidemic Agents