A large and increasing part of the German population has a migrant background. These persons may show major differences in their lifestyle, health beliefs and risk factors compared to the autochthonous German population. This can have a significant impact on the access of migrants to the health system and their participation in prevention programs. To increase the uptake of prevention programs, barriers must be identified and approaches to reduce them should be developed. In Germany, there is a need for prevention programs addressing migrants that are large-scale, evidence-based, sustainable and regularly evaluated.