Abstract
Greater understanding of the cellular interactions associated with tissue factor (TF), activated factor (F) VII and TF-FVIIa complexes is likely to provide considerable clinical benefit. This article reviews current knowledge on the function and regulation of TF and its role in a range of biological processes, including hemostasis, thrombosis and inflammation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Blood Coagulation / physiology*
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Factor VIIa / chemistry
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Factor VIIa / physiology*
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Hemostasis
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Humans
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Inflammation / blood
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Inflammation / etiology
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Lipoproteins / chemistry
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Lipoproteins / genetics
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Lipoproteins / physiology
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Models, Molecular
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Multiprotein Complexes
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Protein Processing, Post-Translational
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Signal Transduction
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Solubility
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Thromboplastin / chemistry
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Thromboplastin / physiology*
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Thrombosis / blood
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Thrombosis / etiology
Substances
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Lipoproteins
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Multiprotein Complexes
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lipoprotein-associated coagulation inhibitor
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Thromboplastin
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Factor VIIa