The tissue factor-factor VIIa complex: procoagulant activity, regulation, and multitasking

J Thromb Haemost. 2007 Jun;5(6):1097-105. doi: 10.1111/j.1538-7836.2007.02435.x.

Abstract

Greater understanding of the cellular interactions associated with tissue factor (TF), activated factor (F) VII and TF-FVIIa complexes is likely to provide considerable clinical benefit. This article reviews current knowledge on the function and regulation of TF and its role in a range of biological processes, including hemostasis, thrombosis and inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Coagulation / physiology*
  • Factor VIIa / chemistry
  • Factor VIIa / physiology*
  • Hemostasis
  • Humans
  • Inflammation / blood
  • Inflammation / etiology
  • Lipoproteins / chemistry
  • Lipoproteins / genetics
  • Lipoproteins / physiology
  • Models, Molecular
  • Multiprotein Complexes
  • Protein Processing, Post-Translational
  • Signal Transduction
  • Solubility
  • Thromboplastin / chemistry
  • Thromboplastin / physiology*
  • Thrombosis / blood
  • Thrombosis / etiology

Substances

  • Lipoproteins
  • Multiprotein Complexes
  • lipoprotein-associated coagulation inhibitor
  • Thromboplastin
  • Factor VIIa