Antibodies to HIV-1: aiming at the right target

Dirk Eggink; Mark Melchers; Rogier W Sanders

doi:10.1016/j.tim.2007.05.006

Antibodies to HIV-1: aiming at the right target

Trends Microbiol. 2007 Jul;15(7):291-4. doi: 10.1016/j.tim.2007.05.006. Epub 2007 Jun 12.

Authors

Dirk Eggink¹, Mark Melchers, Rogier W Sanders

Affiliation

¹ Laboratory of Experimental Virology, Department of Medical Microbiology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, The Netherlands.

PMID: 17566740
DOI: 10.1016/j.tim.2007.05.006

Abstract

HIV-1 evades antibody-mediated neutralization in many cunning ways. The recent structural characterization of a conserved neutralization epitope on the envelope glycoprotein complex (Env) provides clues to the vulnerabilities of the virus. We discuss these observations and explain their relevance for HIV-1 vaccine design.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

AIDS Vaccines / immunology*
Antibody Specificity / immunology*
Drug Design
Epitopes / chemistry
Epitopes / immunology
HIV Envelope Protein gp120* / chemistry
HIV Envelope Protein gp120* / immunology
HIV Infections / immunology
HIV Infections / prevention & control*
HIV-1 / immunology*
Humans
Protein Structure, Tertiary

Substances

AIDS Vaccines
Epitopes
HIV Envelope Protein gp120