Selective oxidation of sulfides to sulfoxides catalyzed by ruthenium (III) meso-tetraphenylporphyrin chloride in the presence of molecular oxygen

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4650-3. doi: 10.1016/j.bmcl.2007.05.073. Epub 2007 May 26.

Abstract

Highly efficient selective oxidation of sulfides to sulfoxides by molecular oxygen catalyzed by ruthenium (III) meso-tetraphenylporphyrin chloride (Ru(TPP)Cl) with isobutyraldehyde as oxygen acceptor has been reported. In large-scale experiment of thioanisole oxidation, the isolated yield of sulfoxide of 92% was obtained and the turnover number reached up to 92,000.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Metalloporphyrins / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Oxygen / chemistry*
  • Ruthenium / chemistry*
  • Sulfides / chemistry*
  • Sulfoxides / chemistry*

Substances

  • Metalloporphyrins
  • Sulfides
  • Sulfoxides
  • ruthenium (III) meso-tetraphenylporphyrin chloride
  • Ruthenium
  • Oxygen