A new cadinane sesquiterpene with significant anti-HIV-1 activity from the cultures of the basidiomycete Tyromyces chioneus

J Antibiot (Tokyo). 2007 May;60(5):332-4. doi: 10.1038/ja.2007.44.

Abstract

A new cadinane sesquiterpene (4beta,14-dihydroxy-6alpha,7betaH-1(10)-cadinene, 1) was isolated from the cultures of the basidiomycete, Tyromyces chioneus. Its structure was established on the basis of spectral measurements (MS, IR, 1D and 2D NMR experiments). 1 showed significant anti-HIV-1 activity with EC50=3.0 microg/ml (SI=25.4).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / isolation & purification
  • Anti-HIV Agents / pharmacology*
  • Basidiomycota / chemistry*
  • Cell Line, Tumor
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, Thin Layer
  • Cytopathogenic Effect, Viral / drug effects
  • Drug Screening Assays, Antitumor
  • Fermentation
  • HIV-1 / drug effects*
  • Humans
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Optical Rotation
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Structure-Activity Relationship

Substances

  • 4,14-dihydroxy-6,7H-1(10)-cadinene
  • Anti-HIV Agents
  • Indicators and Reagents
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes