Abstract
A new cadinane sesquiterpene (4beta,14-dihydroxy-6alpha,7betaH-1(10)-cadinene, 1) was isolated from the cultures of the basidiomycete, Tyromyces chioneus. Its structure was established on the basis of spectral measurements (MS, IR, 1D and 2D NMR experiments). 1 showed significant anti-HIV-1 activity with EC50=3.0 microg/ml (SI=25.4).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / isolation & purification
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Anti-HIV Agents / pharmacology*
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Basidiomycota / chemistry*
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Cell Line, Tumor
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Chemical Phenomena
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Chemistry, Physical
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Chromatography, Thin Layer
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Cytopathogenic Effect, Viral / drug effects
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Drug Screening Assays, Antitumor
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Fermentation
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HIV-1 / drug effects*
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Optical Rotation
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Polycyclic Sesquiterpenes
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Structure-Activity Relationship
Substances
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4,14-dihydroxy-6,7H-1(10)-cadinene
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Anti-HIV Agents
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Indicators and Reagents
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Polycyclic Sesquiterpenes
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Sesquiterpenes