A simple method for detection of major phenotypic abnormalities in myelodysplastic syndromes: expression of CD56 in CMML

Haematologica. 2007 Jun;92(6):859-60. doi: 10.3324/haematol.11118.

Abstract

Using a very simple flow cytometry protocol, we found that CD36 and CD117 on granulocytes and CD56 on monocytes were the major bone marrow phenotypic aberrations in patients with myelodysplasia, including CMML. CD56 on monocytes was associated with CMML. Importantly, phenotypic aberrations were lost on blood cells, except for CD56.

Publication types

  • Letter

MeSH terms

  • CD56 Antigen / analysis*
  • Flow Cytometry / methods
  • Humans
  • Immunophenotyping / methods
  • Leukemia, Myelomonocytic, Chronic / diagnosis*
  • Methods
  • Monocytes / chemistry
  • Monocytes / immunology
  • Myelodysplastic Syndromes / diagnosis

Substances

  • CD56 Antigen