Catalytic activation through metal enolization of nucleophile precursors and synthetic applications to enantioselective Michael additions

Abstract

Catalytic activation methods of nucleophile precursors recently developed in our research group were reviewed in this paper. These include (i) the catalytic double activation method of nucleophile precursors through enol formation and of electrophiles through coordination in alcohols; (ii) the double catalytic activation method by use of both catalytic amounts of chiral Lewis acid and external achiral amine; (iii) the catalytic activation method of nucleophile precursors with a chiral cationic Lewis acid in the presence of molecular sieves; and (iv) the single catalytic activation of nucleophile precursors through metal enolization in alcohol media.