t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia

Delong Liu; Josif Shimonov; Suneeta Primanneni; Yongrong Lai; Tauseef Ahmed; Karen Seiter

doi:10.1186/1476-4598-6-35

t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia

Mol Cancer. 2007 Jun 4:6:35. doi: 10.1186/1476-4598-6-35.

Authors

Delong Liu¹, Josif Shimonov, Suneeta Primanneni, Yongrong Lai, Tauseef Ahmed, Karen Seiter

Affiliation

¹ Division of Oncology/Hematology, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA. delong_liu@nymc.edu

Abstract

Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Review

MeSH terms

Burkitt Lymphoma / drug therapy
Burkitt Lymphoma / genetics*
Burkitt Lymphoma / radiotherapy
Chromosomes, Human, Pair 14 / genetics
Chromosomes, Human, Pair 14 / ultrastructure*
Chromosomes, Human, Pair 18 / genetics
Chromosomes, Human, Pair 18 / ultrastructure*
Chromosomes, Human, Pair 8 / genetics
Chromosomes, Human, Pair 8 / ultrastructure*
Combined Modality Therapy
Female
Genes, Immunoglobulin
Genes, bcl-2
Genes, myc
Humans
Immunoglobulin Heavy Chains / genetics
Karyotyping
Male
Middle Aged
Remission Induction
Translocation, Genetic*

Substances

Immunoglobulin Heavy Chains