Previous studies of the relationship between anxiety and 3-methoxy-4-hydroxyphenylglycol (MHPG) in depression have produced conflicting results. The possibility that different definitions of anxiety may have created these discrepant findings was explored. There was no convincing evidence that MHPG was associated with any of a wide range of different anxiety measurements that encompassed the anxiety concepts of somatic anxiety, psychic anxiety, agitation, or situational stress. The relationships of anxiety ratings to each other were also examined.