Abstract
The analgesic and anti-inflammatory activities of a new alkaloid, 1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin-3-ylamine (compound 1) isolated from Sida cordifolia Linn. were investigated in animal models. In the acetic acid induced writhing model, the compound 1 showed 25.4 (P<0.05) and 52.43% (P<0.01) inhibition of writhing response at doses of 25 and 50 mg/kg body weight respectively. The alkaloid also produced significant increase in the tail flick latency in radiant heat tail-flick method. In Carrageenan induced rat paw edema the compound 1 produced 16.93 and 24.43 % inhibition of paw edema at the doses of 25 and 50 mg/kg body weight respectively at the third hour of study.
MeSH terms
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Acetic Acid
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Analgesics, Non-Narcotic / isolation & purification
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Analgesics, Non-Narcotic / pharmacology*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Behavior, Animal / drug effects
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Carrageenan
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Edema / chemically induced
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Edema / prevention & control
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Female
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Male
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Malvaceae / chemistry*
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Mice
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Pain Measurement
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Quinazolines / isolation & purification
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Quinazolines / pharmacology*
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Rats
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Rats, Long-Evans
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Reaction Time / drug effects
Substances
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1,2,3,9-tetrahydro-pyrrolo(2,1-b)quinazolin-3-ylamine
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Analgesics, Non-Narcotic
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Anti-Inflammatory Agents, Non-Steroidal
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Plant Extracts
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Quinazolines
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Carrageenan
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Acetic Acid