Coordination of cell proliferation and differentiation: finding a GEM in the root?

Marjolein Wildwater; Inge The; Sander van den Heuvel

doi:10.1016/j.devcel.2007.05.005

Coordination of cell proliferation and differentiation: finding a GEM in the root?

Dev Cell. 2007 Jun;12(6):841-2. doi: 10.1016/j.devcel.2007.05.005.

Authors

Marjolein Wildwater¹, Inge The, Sander van den Heuvel

Affiliation

¹ Division of Developmental Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

PMID: 17543854
DOI: 10.1016/j.devcel.2007.05.005

Abstract

How cells acquire specific fates in conjunction with cell division is a major developmental question. In a recent issue of Nature, Caro and colleagues describe the Arabidopsis protein GEM, which interacts both with DNA-replication and transcriptional regulators (Caro et al., 2007). The results are surprisingly reminiscent of the dual functions reported for Geminin in animals.

Publication types

Review

MeSH terms

Animals
Arabidopsis Proteins / metabolism*
Cell Cycle / physiology*
Cell Cycle Proteins / metabolism
Cell Cycle Proteins / physiology
Cell Differentiation*
Cell Proliferation*
DNA Replication / physiology
Embryonic Development / physiology
Geminin
Gene Expression Regulation, Developmental / physiology
Humans
Intracellular Signaling Peptides and Proteins
Regulatory Elements, Transcriptional

Substances

Arabidopsis Proteins
Cell Cycle Proteins
GEM protein, Arabidopsis
GMNN protein, human
Geminin
Intracellular Signaling Peptides and Proteins